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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract:

Antithrombin and protein C are two crucial members in the anticoagulant system and play importantCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased proteinC activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variantc.572_574delAGA in .This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 30-35 doi: 10.1007/s11684-009-0005-x

Abstract: The role of high sensitivity C-reactive protein (hsCRP) in predicting prognosis after stroke in the Asian

Keywords： C-reactive protein     inflammation     stroke    

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The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract:

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family.

Keywords： protein kinase C ?     signal transduction     neurogenic disease    

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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 541-550 doi: 10.1007/s11684-020-0780-y

Abstract: This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc.Here, we revisit current methods used to target c-Myc and discuss the important functional nodes relatedto c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny

Keywords： synthetic lethality     undruggable     transcription factor     c-Myc    

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Investigation of hydrolysis conditions and properties on protein hydrolysates from flatfish skin

Hua ZHANG, Hongji ZHU, Shipeng WANG, Weihua WANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 3,   Pages 303-311 doi: 10.1007/s11705-013-1341-6

Abstract: based on Box-Behnken design, was used to optimize the enzymatic hydrolysis conditions of flatfish skin proteinThe optimal hydrolysis conditions were as follows: pH 7.3, temperature 51.8°C, and the enzyme/substrate

Keywords： flatfish skin     protein hydrolysates     metal chelating activity     reducing power    

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Probing the catalytic activity of M-N

Fan Ge, Qingan Qiao, Xin Chen, You Wu

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5,   Pages 1206-1216 doi: 10.1007/s11705-020-2017-7

Abstract: Electronic structure analysis reveals one of the reasons for the higher activity of Co-N O and Ni-N

Keywords： M-N-C catalyst     oxygen doping     oxygen reduction reaction     catalytic activity     density functional theory    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: this study is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, proteinphosphatase 2A (PP2A) activity, and on tau phosphorylation., and the phosphorylation levels of PP2A Y307 and tau at different sites, as well as PP2A activity wereHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.Multiple factors may be involved in the cellular regulation of PP2A activity.

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 66-72 doi: 10.15302/J-FASE-2015047

Abstract: The immune mapped protein 1 (NcIMP1) was identified as a membrane protein, and a previous study indicatedin the recombination plasmid pcDNA-IMP1, which was used for the intramuscular immunization of BALB/c

Keywords： Neospora caninum     immune mapped protein 1 (IMP1)     vaccine candidate     BALB/c mice    

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Joint association of physical activity/screen time and diet on CVD risk factors in 10-year-old children

Pfeiffer, Joey C. Eisenmann

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 428-435 doi: 10.1007/s11684-012-0232-4

Abstract: While several studies examined the effect of single behaviors such as physical activity (PA), sedentaryself-reported PA, ST, or dietary intake were not directly related to CVD risk in this sample, higher activity

Keywords： exercise     sedentary behavior     metabolic syndrome     health behavior     adolescents     TV time     healthy eating index    

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A facile synthesis of high activity cube-like Pt/carbon composites for fuel cell application

Reza B. MOGHADDAM, Samaneh SHAHGALDI, Xianguo LI

Frontiers in Energy 2017, Volume 11, Issue 3,   Pages 245-253 doi: 10.1007/s11708-017-0492-4

Abstract: High activity catalyst with simple low-cost synthesis is essential for fuel cell commercialization.The Pt grow with Vulcan XC-72 or Ketjen black, respectively, and then treated for 5.5 h at 185ºC (i.eOptimization of the Pt /K composites leads to Pt /K that has been treated for 10 h at 185ºC.Johnson Matthey (JM)Pt/C catalysts.. 6–7 nm for Pt /K), however, Pt /K has a significantly better FA oxidation activity.

Keywords： synthesis     cube-like Pt     Pt/C composite     catalyst     impedance    

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Influence of Fe on electrocatalytic activity of iron-nitrogen-doped carbon materials toward oxygen reduction

Lin LI, Cehuang FU, Shuiyun SHEN, Fangling JIANG, Guanghua WEI, Junliang ZHANG

Frontiers in Energy 2022, Volume 16, Issue 5,   Pages 812-821 doi: 10.1007/s11708-020-0669-0

Abstract: Among different M-N-C electrocatalysts, the series of Fe-N-C materials are highly favored because oftheir high ORR activity.It is thus very critical to explore the influences of Fe on the ORR electrocatalytic activity, whichwill, in turn, guide the design of Fe-N-C materials with enhanced performance.Herein, a series of Fe-N-C electrocatalysts are synthesize and the influence of Fe on the ORR activity

Keywords： oxygen reduction reaction     Fe-N-C     active sites     Fe addition     second heat treatment    

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Tuning nitrogen defects and doping sulfur in carbon nitride for enhanced visible light photocatalytic activity

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 1,   Pages 93-101 doi: 10.1007/s11705-022-2175-x

Abstract: Defect construction and heteroatom doping are effective strategies for improving photocatalytic activityof carbon nitride (g-C3N4).With the increase in N defects, the photocatalytic activity showed a volcanic trend.activity.S-doped g-C3N4 exhibited 11.25 times higher photocatalytic activity than pure g-C

Keywords： g-C3N4     nitrogen defect     sulfur doping     photodegradation     plasma    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: suppressor XAF1 gene expression in digestive system cancers, we studied XAF1 gene promoter transcription activityThe promoter transcription activity was determined by dual-luciferase report assay, and enhanced greenfluorescent protein (EGFP)-positive cells were detected by fluorescence microscope.The dual-luciferase reporter assay showed that the promoter transcription activity in digestive systemExpression of green fluorescent protein (GFP) under the control of XAF1 promoter in the three digestive

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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Enhanced Poly(ethylene terephthalate) Hydrolase Activity by Protein Engineering Article

Yuan Ma, Mingdong Yao, Bingzhi Li, Mingzhu Ding, Bo He, Si Chen, Xiao Zhou, Yingjin Yuan

Engineering 2018, Volume 4, Issue 6,   Pages 888-893 doi: 10.1016/j.eng.2018.09.007

Abstract: around the substrate-binding groove in order to create novel high-efficiency PETase mutants through proteinThe I179F mutant showed the highest activity, with the degradation rate of a PET film reaching 22.5 mgThus, this study has created enhanced artificial PETase enzymes through the rational protein engineering

Keywords： Polyesterase     PET degradation     Cell-free protein synthesis     Polyester     PETase    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Title Author Date Type Operation

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke

Jiangtao YAN, Rutai HUI, Daowen WANG

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Journal Article

Investigation of hydrolysis conditions and properties on protein hydrolysates from flatfish skin

Hua ZHANG, Hongji ZHU, Shipeng WANG, Weihua WANG

Journal Article

Probing the catalytic activity of M-N

Fan Ge, Qingan Qiao, Xin Chen, You Wu

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Journal Article

Joint association of physical activity/screen time and diet on CVD risk factors in 10-year-old children

Pfeiffer, Joey C. Eisenmann

Journal Article

A facile synthesis of high activity cube-like Pt/carbon composites for fuel cell application

Reza B. MOGHADDAM, Samaneh SHAHGALDI, Xianguo LI

Journal Article

Influence of Fe on electrocatalytic activity of iron-nitrogen-doped carbon materials toward oxygen reduction

Lin LI, Cehuang FU, Shuiyun SHEN, Fangling JIANG, Guanghua WEI, Junliang ZHANG

Journal Article

Tuning nitrogen defects and doping sulfur in carbon nitride for enhanced visible light photocatalytic activity

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Enhanced Poly(ethylene terephthalate) Hydrolase Activity by Protein Engineering

Yuan Ma, Mingdong Yao, Bingzhi Li, Mingzhu Ding, Bo He, Si Chen, Xiao Zhou, Yingjin Yuan

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article